Archive for the ‘Funding’ Category

University Overhead Under Siege

Friday, March 22nd, 2013
harvard_chemistry_mallinckrodt_building

Mallinckrodt Building, the Home to Chemistry and Chemical Biology at Harvard

There was a fascinating article in The Boston Globe this week on an attempt by the Obama administration to curtail the high rates of research funding doled out to elite universities as overhead. Overhead, formally called “indirect costs”, is typically awarded as a percentage of the funding for a research grant. The purpose of indirect costs is to compensate the institution for expenses that are difficult to ascribe to any single project—e.g., the cost of electricity, water, administration, maintenance, building/instrument depreciation, and more. Each institution negotiates its overhead rate (as a percentage) with the government, and some of the most prestigious universities have huge rates. For instance, Harvard has a rate that stands at 69%, while the national average is 52%. These funds simply enter the universities’ general budgets; once awarded, there is no requirement that they go towards funding expenses associated with research.

Last year, the Obama administration attempted to curtail high overhead rates by setting a single rate for all universities, but the largest schools were successful in protecting their lions’ share by lobbying against the proposed changes. From the article:

Demands for a fairer system have been issued for years, the inequities cited in numerous reports. Vedder and other critics contend the varying overhead reimbursement rates contribute to a widening gap between rich and poor schools. And smaller, less prestigious schools around the country are tired of being shortchanged, particularly when the prime beneficiaries are extremely wealthy schools like Harvard, which has a $30.7 billion endowment.

Bin Guo, a cancer researcher at North Dakota State University who wrote to the government in support of an overhaul, said he supports a flat rate set between 40 and 50 percent. North Dakota State receives a 44.5 percent overhead rate.

“This will eliminate the waste of federal funds at many large institutions that spend the indirect cost on nonresearch-related programs,” Guo said. “If the NIH can save this extra money, they can support more research grants.”

Harvard received $656 million last year in federal research funding, and about $175 million of that was overhead compensation. Harvard maintains that its rate is high because the type of research that is done there requires high-tech facilities and equipment, in addition to being located in a region with high labor and construction costs.

It was interesting to learn that after World War II, when the U.S. government started funding university research in earnest, the rate for overhead was 8%. It rose to 20% by 1965, when the government started allowing individual institutions to negotiate their own rates. Some schools’ rates rose past 90% before coming back down when government audits revealed inappropriate spending (like on sports tickets).

It certainly makes sense for the government to pay indirect costs, but I don’t see a good reason why a school like Harvard should get much more than another school in the same geographic area. Harvard will already secure more in indirect costs by virtue of their professors’ winning more grants. Of course, the main reason for Harvard’s sky-high rate is probably that the school paid for a better team of negotiators and budget planners. It’s another example of the rich getting richer.

When I transitioned from college (at NYU) to grad school (at Harvard), I was amazed at how much more administration there was at my new school. At Harvard, every professor had an administrative assistant (some had more than one), while at NYU, such assistants were rare. At Harvard, the department’s mail room was staffed by two people (not counting the guys in shipping). Harvard’s financial office had an army of people, and each major instrument facility (NMR, MS, X-Ray) had a dedicated staff member. At NYU, these staffers serviced multiple instruments. I was also amazed that professors at Harvard only had to teach one course per year, and when doing so, could lean heavily on an army of teaching assistants. In hindsight, one wonders how much of this excess (relative to smaller R1 schools) is necessary or worthwhile.

Combatting Chemophobia

Friday, February 1st, 2013

Chemical Ed with GogglesThe annual ScienceOnline 2013 conference is taking place in North Carolina, and chembloggers Carmen Drahl and Dr. Rubidium are running a session tomorrow on chemophobia. You can follow updates on Twitter labeled with the hashtag #chemophobia.

Personally, I think the greatest failure of our field over the past three decades has been the steady decline of the public image of chemistry. Our “brand” has steadily deteriorated from an apex of “better living through chemistry” in the 1970s to the ever-worsening current climate where “chemicals are bad” and products are nonsensically advertized as “chemical-free”.

There certainly are cases where specific chemists and chemicals have had horrific consequences for the public (e.g., thalidomide or the Bhopal disaster), but surely these cases are balanced by the numerous ways that chemistry has improved modern life: from countless new pharmaceuticals that improve health to a wide array of new materials that make modern technology possible. That’s all “chemistry” and “chemicals”, but the average person-on-the-street would probably not associate these advances with our science.

Of course, this is a blog for chemists, so there’s no sense wasting time here celebrating all of the benefits of chemicals and chemistry. Rather, why don’t we focus on how utterly stupid our field is with regard to communicating these benefits? Despite the manifestly dire state of the public image of chemistry, chemists continue to do nothing to correct the problem.

But, Paul…is it really a problem? Who cares if the public dislikes chemicals? So long as chemists know better, we will continue doing good science. Why should we be distracted by general ignorance?

The problem with that argument is that we live in a democracy. For a democracy—where the People govern by voting—to function efficiently, the electorate must be educated and informed. The steady decline of chemistry’s public image is a massive problem, because it erodes support for our field. Taxpayers fund our research, and if they are convinced that not only is chemistry not helping the world, it is hurting it, then what is going to stop politicians from cutting funding? This is already occurring. Look at how many Americans vilify scientists who support the highly (un)controversial theory of evolution. We also spend many, many times more money on the DoD than scientific research because the public is generally much more concerned about the threat of foreign dictators than the combined threats of insidious disease and the global energy crisis. Seem stupid? Well, turn on the news tonight. What are people talking about, the Middle East or cancer? And what’s worse than people not knowing anything about chemistry is when they “know” incorrect negative information about chemistry. That’s basically where we are.

Hey Paul, isn’t this something the ACS should handle?

Yes! Actually, it is something all of us should take responsibility for handling to some degree, but the ACS should be at the forefront. This brings me to the point: WHAT THE HELL HAS THE ACS BEEN DOING FOR THE PAST 30 YEARS? As far as I can tell, very little in the public-image battle, and the miserable status quo is all the evidence you need that our professional society has failed its mission in this regard.

OK, wise guy, what should the ACS be doing?

I can think of a number of things, but let me give you two: one from the executive level and one from the grass-roots level. First, the ACS needs to get a handle on misinformation in the media. When someone blurts “chemical-free” into a microphone or opines about the hazards of a compound with zero supporting evidence, the ACS should have someone step up and provide a rebuttal. We need a “war room” at ACS headquarters that monitors all major media outlets and contacts editors and producers when something is wrong. The war room should have experts trained in public communication who are camera-ready 24 hours a day and a TV studio on-site for satellite interviews. Reporters are getting lazier; we must adapt. At the grass-roots level, the ACS needs to do a better job organizing outreach efforts and coordinating volunteer chemists to run these programs. More on that below.

Whoa. Volunteer chemists and outreach programs? What are you talking about?

I think it is important that every chemist spend some time engaging the general public for the purposes of education and promoting the benefits of our field. Let me toss out a ball-park figure: 5% of your time allotted to chemistry.

You want me doing what, exactly?

Pretty much anything where you are bringing science/chemistry to a population not already intimately involved in the field. I am not talking about writing essays for Angewandte or leaving comments on In the Pipeline. I am talking about: (1) judging kids’ science fairs, (2) writing letters to the editors of newspapers to correct misinformation, (3) running or volunteering at a local science club, (4) explaining your research at a science cafe, (5) volunteering to talk to a middle-school science class, (6) developing a lab exercise for high schoolers based on your research, (7) making a science Web site for a general audience, (8) making YouTube videos pretending you are “Phil Nye the Chemistry Guy”, (9) editing Wikipedia, (10)…   need I go on? Anything. Anything! There are thousands of possibilities. If you don’t think you have a good idea, other people should have plenty of ideas in need of volunteers.

You think this will work?

Yes. I believe it will help. I think that education and outreach, or “E & O” in NASA parlance, is exactly what kept a largely overpriced set of shuttle missions in operation for so long. Spacemen realize that they need the public on their side, so they appeal to the public. I assume astronauts on space stations have more important scientific activities they could be doing than giving interviews to the yentas on The View, but NASA has the big picture in mind. If NASA could keep the space shuttles up so long, think about all of the additional funding we could bring to a field of science that is much more successful at improving people’s lives.

What’s in it for me?

Lots of things: (1) you’ll become better at communicating and teaching technical material, (2) you’ll feel good having taught someone something, (3) you’ll be giving back to society – was there a role-model or teacher when you were young that made you want to pursue a career in science?, (4) you are making the world less dumb, one person at a time, (5) in thinking about fundamental concepts and how to explain/teach them, you will invariably come up with new ideas. Sometimes it’s nice to think about areas of chemistry outside your focus of research, (6) you will help to improve the funding climate by persuading voters chemistry is valuable.

Bah. Those are worthless. I can’t list those on my CV!

Actually, you can list outreach activities on your CV. They may even make you seem human, you robotic hardass.

Seriously, my boss/advisor won’t care. Actually, I’ll get in trouble because he views them as a waste of time.

Public engagement should be a shared responsibility. Perhaps the reason almost nobody pitches in is because “why should I do it if the guy over there doesn’t?”  We need to find ways to incentivize desired behavior. Maybe a small outreach component for Ph.D. theses? Maybe make it part of tenure packages?

But Paul, I went through 11 years of university training to become a high-powered research machine. I am God’s gift to chemical research. I can think of nothing more inefficient than removing me from the bench to muck around with third-graders. Can’t we just hire professional outreach people so I can be left alone?

First, you are going to be able to bring things to the table that an education professional would not. Second, if you are truly “God’s gift to chemical research”, then you are a rock star. People love rock stars of any field. That is why we are willing to watch events like curling in the Olympics. You will be a great help! Also, get over yourself! Astronauts frequently give interviews while working in space. I assume there are probably some experiments they could be doing, but NASA recognizes the importance of education and interacting with the public.

Paul, I am too busy, go away.

What if everyone were too busy? Everyone is too busy! You can make a little time for this. C’mon.

Paul, I am still unconvinced this is actually worth my time.

Fine. You are a selfish jackass. I hope there are enough good chemists out there who can make up for your dereliction.

 

Folks, if we don’t start getting serious about addressing chemophobia, we are going to find ourselves in a bad, bad place as a profession, and the consequences for mankind won’t be pretty either.

The Night Shift

Tuesday, January 8th, 2013

 caltech_loading_cropped

That is not a photo of a Best Buy on the last day of shopping before Christmas. It is the parking lot outside of the chemistry buildings at Caltech, on a Monday night, at 9 pm. Well, it’s not really a parking lot, either. It is a loading area where campus parking restrictions are not enforced after the close of business. There are no marked parking stalls, but every single space in which you could conceivably fit a car without blocking the path of traffic is taken.

At 9 pm. And this pretty much happens every night.

If the NSF ever finds itself looking for a simple way to communicate the value the public gets for each dollar that goes into fellowships and stipends for grad students, a photo of this parking lot might be as effective as any shot taken inside the labs.

UK to Slash Funding for Organic Synthesis

Thursday, August 18th, 2011

This is going to get ugly.

The United Kingdom’s EPSRC—akin to the NSF in the United States—is going to slash the funding of research in synthetic organic chemistry.  In response, the country’s synthetic organic chemists have taken to the streets and set fire to several buildings written a short letter to Prime Minister David Cameron expressing their frustration.

This battle has been shaping up for a long time, and it looks as though it is finally coming to a head.   I think there are tenable arguments in support of both sides of the issue; any decision simply boils down to where your priorities lie.

On the anti-synthesis side, you have those who feel that organic synthesis has reached an area of diminishing returns.  Proponents of the cuts will argue that organic synthesis is a mature field where new advances are modest and unlikely to have major industrial applications.  You also have those who believe that total synthesis—which still seems to constitute a major focus of research in this field—is a largely fruitless exercise where molecules ostensibly made for potential therapeutic activity are actually made just for the sake of making nasty-looking molecules.

While many people do question whether organic synthesis is still interesting, the strongest argument against it probably runs closer to a cost-benefit analysis…  Yes, synthesis can be interesting, but science funding is a zero-sum game and there are other areas of research that are more interesting and/or valuable to society.  I have to think that the recent downturn in the pharmaceutical industry—including the shuttering of Pfizer’s R&D operation in Sandwich—probably strengthens this argument.  The supporters of the budget realignment can argue that we should scale down the training of synthetic chemists now that there are fewer jobs for them.  There are also people who believe that the demise of natural products synthesis in academia has been unreasonably delayed by the historical popularity of the field and the large population of practicing synthetic chemists who stand to benefit by protecting it (e.g., making sure grants for it get funded, etc.)

On the pro-synthesis (anti-realignment) side, you have those who defend the field by pointing out its historical importance, its sustained popularity, its direct applicability to industry, and its potential application in medicine.  With respect to the new criteria for funding, pro-synthesis people can argue the chemistry projects that should be funded are the ones that represent the best science—regardless of the sub-field.  In other words, the synthetic projects that were funded in the past were funded because they were the best projects proposed.  Slashing funding to synthesis will leave these talented chemists out in the cold and will lead to the funding of scientifically inferior projects in other sub-disciplines of chemistry.

Another argument against the realignment in funding is that politicians are messing with scientific funding based on possible misperceptions about various projects’ potential economic value.  The letter to Cameron stresses that the government is overlooking the many contributions of organic synthesis to the UK’s economy.  It should also be noted that EPSRC’s definition of “synthetic organic chemistry” goes beyond total synthesis to include areas like supramolecular chemistry.

It’ll be interesting to see how this battle ends.  If one thing is certain, it is that governments are becoming less shy about dictating how science funding is allocated.  That is, legislators are getting more involved in selecting what types of projects can (and can’t) be funded.  Many people feel that the decision of what science projects to fund should be left to scientists, who are experts in their fields, but the fact of the matter is that science funding is an appropriation of taxpayer money.  Legislators—who are elected by the taxpayers to act in their proxy—definitely have the authority to place specific constraints on science funding and are not necessarily acting against the best interests of society by limiting how this money is spent.

If nothing else, this latest news provides yet another reason for chemists not to ignore the broader public when it comes to justifying their work and communicating its value.

The Sezen Files – Part I: New Documents

Thursday, July 7th, 2011

ChemBark Investigates

Now that C&EN has blown the cover off of this story, I am rushing these posts to press.  I’m not sure when the next installment is coming; there is a ton of information to process.

ChemBark is now in possession of 167 pages of information directly pertinent to the finding of scientific misconduct against Dr. Bengu Sezen (formerly) of Columbia University.  The files relate to investigations conducted by both Columbia University (CU) and the Office of Research Integrity (ORI) in the United States Department of Health and Human Services (DHHS).  In November 2010, ORI announced its finding that Sezen was responsible for 21 instances of scientific misconduct, and the organization subsequently barred her from receiving federal funding for five years.

The documents were obtained by ChemBark via a Freedom of Information Act (FOIA) request submitted on 29 November 2010.  The documents were finally sent on 22 June 2011—over six months past the date of the original request, but a mere two days after ChemBark mailed a friendly reminder to DHHS by U.S. Certified Mail.

The files have been heavily redacted by Carol Maloney, who is Director of the Division of FOIA Services at DHHS.  Very few names other than that of Dr. Sezen remain in the documents, including only one single instance of Dalibor Sames (Sezen’s advisor at Columbia and co-author of several retracted papers).  In making her redactions, Maloney asserted FOIA exemptions (b)(6) and (b)(7)(c), which are intended to protect the personal privacy of parties involved in the investigation.  Statements within these 167 pages of documents allude to the existence of more than 10,000 pages of documents related to the investigation.  While the set of documents obtained by ChemBark has been heavily redacted and only represents a small sample size of the body of documents that exist, the information contained in them paints a vivid picture of what was unquestionably a sustained rampage of data fabrication by Sezen, and later, an equally egregious campaign by her to avoid punishment.  The depth of the deception and its tragic consequences are manifest within the investigatory record, and at times, the machinations of Sezen seem so far-fetched and desperate as to be comedic.

In this series of posts, ChemBark will go through the details of the case most pertinent to the chemical community.  The purpose of this endeavor is to inform the community of the details of the case with an eye on analyzing what transpired and learning from it.  Fabrication of data might be the most heinous crime that can be perpetrated against science, and while “negative” stories like this one often paint our field in a bad light, we cannot afford to ignore them.  Almost six years have passed since the first reports of key details about this case were published on the predecessor to ChemBark.  Unfortunately, the coverage provided by traditional outlets for scientific news has been superficial and woefully inadequate.  It has obviously taken an extraordinary amount of time to uncover the details of the investigation, but a few delayed blog posts are better than nothing.  I have long maintained in previous coverage of this story that there is plenty for the chemical community to learn from this case, and these documents verify that.

Associated Documents

3 December 2010 – Acknowledgment of receipt of ChemBark’s FOIA request
8 December 2010 – Denial of ChemBark’s request for expedited processing
20 June 2011 – Follow-up letter to DHHS FOIA Office
22 June 2011 – Cover letter from DHHS with Bengu Sezen Investigation FOIA Materials
22 June 2011 – FOIA Materials for Bengu Sezen Investigation

Upcoming:

The Sezen Files – Part II: Unraveling the Fabrication
The Sezen Files – Part III: And What of Sames?
The Sezen Files – Part IV: Lessons and Lingering Questions
The Sezen Files – Part V: Wrap Up

Video Grant Proposals

Tuesday, April 12th, 2011

Grand Challenges Canada is a nonprofit organization that strives to improve health care in developing countries.  The organization funds research in a rather innovative manner: they lay down challenges and require that PIs not only submit written proposals, but also two-minute video summaries.  The videos get posted to the Web where visitors can vote on them to assist the program in awarding funds.

I love this experiment in grant “writing”.  While this specific program is driven by a private organization, I see no reason why public agencies wouldn’t at least consider something similar.  I think that scientists need to be cognizant of the fact that most of our funding originates from the public, and we should feel a responsibility to keep the people informed of what we’re doing with their money and why it is important.  The value of this endeavor is magnified in times where budgets are tight; in politics, it is much better to be on offense than defense.

And just to be clear, I am *not* saying we should allocate grant money based solely on an online ballot open to the general public.  That is not what is going on here, anyway.  Rather, the willingness of the PI to engage the public (and her effectiveness is doing so) is important to the funding organization, so the organization has made this aspect a part of the scoring.  That makes perfect sense to me.

You can view the videos for the first challenge here.   Ratmir, an old labmate of mine, and the JACS Twitter feed, @J_A_C_S, brought this competition to my attention.  Ratmir’s video proposal on the use of paper as a platform for cell-based diagnostic assays can be viewed and voted on here.  It’s pretty well produced.  I hope you like progressive house music.

So far, the most popular video seems to belong to Krishna Khairnar, who is developing a field-based rectal swab collection system for diagnosing parasites.  I think his success might be something akin to Sanjaya Malakar’s on American Idol.  At one point in the video, Dr. Khairnar holds up his fecal-collection device.  It looks scary, and the fact that he doesn’t explain how it’s used makes it even scarier.  Also, I think he didn’t pay attention to the rules—the organizers cut him off mid-sentence at the two-minute mark.  I’d say “FAIL”, but he’s winning…